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Sabinsa Builds Science Behind Weight Loss Blend

May 5, 2008

Related topics: Phytochemicals, plant extracts, Weight management.

Sabinsa's weight management ingredient, LeanGard, may boost weight loss and cut body fat,according to a new study from the company that builds the science behind the product.

Supplementation with the proprietary ingredient blend led to 6.4 per cent greater weight loss, and a 6.97 greater loss of body fat than placebo, according to results from the randomised, double blind, parallel-controlled study.

Lakshmi Prakash, PhD, VP innovation and business development at Sabinsa told NutraIngredients that the study has not yet been published in a peer reviewed journal, but an article is being prepared for publication in the near future. NutraIngredients.com has not seen the full data.

The study sees the company build the science behind its blended ingredient - a necessary endeavour if the company wants to stand out in an increasingly competitive weight loss market.

Approximately one third of Americans are obese and Euromonitor International estimates the US weight management supplements market to be worth $3.93bn, while the European market is valued at $0.93bn in 2005.

LeanGard is a blend of ForsLean, Garcitrin and Bioperine. The first is an extract derived from Coleus forskohlii roots and reportedly helps to build lean body mass and optimize body composition through cAMP (cyclic adenosine monophosphate) activation.

Garcitrin contains calcium salt hydroxycitric acid (HCA) and garcinol, a polyisoprenylated benzophenone isolated from Garcinia cambogia and Garcinia indica. These fruits are thought to reduce fatty acid, lipid synthesis as well as to improve lean body mass.

Standardized piperine Bioperine is extracted from black pepper and is claimed to increase the absorption of nutrients in nutritional supplement formulations.

New data

The researchers, led by Noor Khan, MD, from Shifaa Hospital in Bangalore, India, recruited 50 overweight and obese subjects, (26 women) aged between 25 and 55, and randomly assigned them to receive either a daily dose of the proprietary blend (500 mg) or placebo for 12 weeks.

At the end of the study period, 90 per cent of participants in the LeanGard group achieved more than five per cent reduction in body weight, while no one in the placebo group achieved this weight loss. This translated to a 7.45 per cent reduction in BMI, compared to a 1.09 per cent change in the placebo group.

An increase in the basal metabolic rate (BMR) of 4.5 per cent was also observed in the LeanGard group, while people in the placebo group experienced at a 0.64 per cent mean increase.

The ingredient was first presented at the Slimming Ingredients, Germany conference in March 2007.




Sabinsa Unveils Weight Management Ingredient LeanGard®

March 29, 2007.

Related topics: Phytochemicals, plant extracts, Weight management

Sabinsa Corporation is combining the forces of three of its established patented ingredients in the unveiling of a new weight management ingredient LeanGard.

The company will present LeanGard for use in dietary supplements at the Slimming Ingredients Conference in Berlin. The ingredient is commercially ready and the company said it would most likely see its first sales in the United States.

Sabinsa hopes to market the proprietary ratio of its clinically researched ingredients, Forslean, Garcitrin and Bioperine, as a branded ingredient recognizable to consumers in an increasingly competitive weight loss market.

Approximately one third of Americans are obese and Euromonitor International estimates the US weight management supplements market to be worth $3.93bn, while the European market is valued at $0.93bn in 2005.

Sabinsa wants to differentiate itself from those products that promote rapid weight loss at any physical cost for cosmetic purposes and instead highlight the body of science behind its combined ingredients.

"We're trying to approach this from a health stand-point rather than just a superficial stand point," Sabinsa president Todd Norton told NutraIngredients-USA.

Sabinsa's ingredient is designed to promote lean body mass, suppress appetite and enhance thermogenic activity.

"LeanGard is a combination of three patented and clinically tested ingredients that Sabinsa has had for years and has combined into a proprietary blend to combine different facets of weight management issues," said Norton.

ForsLean is an extract derived from Coleus forskohlii roots and helps to build lean body mass and optimize body composition through cAMP (cyclic adenosine monophosphate) activation.

Garcitrin contains calcium salt hydroxycitric acid (HCA) and garcinol, a polyisoprenylated benzophenone isolated from Garcinia cambogia and Garcinia indica. These fruits are thought to reduce fatty acid, lipid synthesis as well as to improve lean body mass.

Standardized piperine Bioperine is extracted from black pepper and has been shown to increase the absorption of nutrients in nutritional supplement formulations.

Forslean helps to build lean body mass and maintain healthy body composition through a cAMP mediated action.

While LeanGard has not been put to clinical trial yet, there is a protocol currently being designed for a weight management study, according to Norton.

"Standing alone the ingredients have all proved themselves safe and effective," he said.

For the time being, the ingredient is geared to the US dietary supplement market due to regulatory issues.

"Right now the product is positioned as a dietary supplement but the forward view is that there may be other applications in the future," said Norton. "It still doesn't cross the threshold in some instances, so there's still a little bit of work to do."

The company would like to get Generally Recognized as Safe (GRAS) status for the ingredient for use in functional food, as well as get it through regulatory hoops for use in supplements in Europe.

Dr. Lakshmi Prakash, vice president of innovation and business development with Sabinsa, will present LeanGard Friday at Slimming Ingredients in Berlin.




Sabinsa to Highlight New Weight Management Composition LeanGard® at the 2007 Slimming Ingredients Conference

March 27, 2007.

Lakshmi Prakash, Ph.D., vice president of innovation and business development with Sabinsa Corporation will be discussing the company’s new weight management composition, LeanGard®, on Friday, March 30, 2007 at 11 a.m. as part of the Slimming Ingredients Conference being held in
Berlin, Germany. LeanGard is a combination of three of Sabinsa’s patented, clinically researched ingredients, ForsLean®, Garcitrin® and Bioperine® and can help promote lean body mass, suppress the appetite and enhance thermogenic activity.

“With nearly two thirds of the world’s population overweight, the need for effective products with extensive scientific validation is more important than ever,” noted Dr. Prakash. “The unique aspect of this conference is that it brings together companies that have a shared philosophy about the value of research and who are looking to push the industry away from simply focusing on the next hot ingredient.”

LeanGard consists of a proprietary ratio of ForsLean, Garcitrin and Bioperine. ForsLean is an extract derived from Coleus forskohlii roots, and the only known plant source of forskolin, a natural compound that has been shown to increase lean body mass and help optimize body composition through cAMP activation. Garcitrin is a composition of calcium salt hydroxycitric acid (HCA) with garcinol, a polyisoprenylated benzophenone isolated from Garcinia cambogia and Garcinia indica fruits, which reduces fatty acid and lipid synthesis and improves lean body mass. Bioperine is a standardized piperine composition derived from black pepper extract that has been shown to increase the absorption of nutrients in nutritional supplement formulations.

Sabinsa Corporation, founded in 1988, is a manufacturer and supplier of herbal extracts, cosmeceuticals, minerals and specialty fine chemicals. Sabinsa’s mission is to provide alternative and complementary natural products for human nutrition and well-being. Over the past nine years, Sabinsa has brought to market more than 50 standardized botanical extracts and privately funded several clinical studies in conjunction with prestigious institutions in support of these products. With more than 100 scientists working full time conducting ongoing research both in India and the United States, Sabinsa continues to develop and patent phytonutrients for the world market. All products intended for human consumption are certified Kosher.
For more information visit www.sabinsa.com

The Slimming Ingredients Conference is a professional exhibition dedicated to covering the latest innovations and trends in weight loss and weight management. The exhibition is open only to companies that provide clinical trials for their ingredients and/or products.
For more information visit www.isanh.com/slimming/